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KMID : 0378619980140000159
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Baptist Hospital Medical Journal
1998 Volume.14 No. 0 p.159 ~ p.169
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Effect of Comnon Bile Duct Ligation on Glyoxalase Ⅱ Activity in Ethanol Intoxicated Rat Liver
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Abstract
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To understand the biochemical background of alcohol hazards in hepatobiliary disease, the activies of the rat liver cytosolic and mitochondfial glyoxalase-ll (GLO-Ⅱ) were measured in cholestasis induced by common bile duct (CBD ligation after chronic ethanol intoxication. and in cholestasis before acute ethanol intoxication.
GLO-Ⅱ activities in the rat´s liver cytosol and mitochondria showed more decrease when CBD was ligated after chronic ethanol intoxication than that in the CBD ligation alone.
On the other hand, when CBD was ligated after chronic ethanol intoxication, the value of Vmax of the liver cytosolic and. miochondrial GLO-Ⅱ decreased significantly than that in the CBD was ligated alone. However the values of Km of the liver cytosolic and mitochondrial GLO-Ⅱ did not change in the all experimental groups.
Viewed from above results, when chronic ethanol intoxication is combined with cholestasis. GLO-Ⅱ in the liver seems to be decrease its activity than that in cholestasis, and the cause of the decrease is thought to be decreased biosynthesis. Accordingly. this result will be the datum supporting that alcoholic drink to be enzyrnologically harmful in hepatobiliary disease.
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